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KMID : 0861019990140020051
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Korea Journal of Herbology
1999 Volume.14 No. 2 p.51 ~ p.59
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Effect of Banhasasimtang on carbon tetrachloride induced hepatoxicity in rats
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朱旺錫/Ju, Wang-Seog
朴賢俊/尹炳局/鄭成伊/朴宣東/Park, Hyun-Jun/Yun, Byoung-Guk/Jung, Sung-Yi/Park, Seon-Dong
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Abstract
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The purpose of this study is to observe the effect of Banhasasimtang on serum reaction in CCI₄ treated rats.
In this study the experimental rats divided five group(Normal, Control, Sample A, Sample B and Sample C group)
Under the same condition Normal group was fed basal diet and water, Control group was injected carbon tetrachloride(CCI₄ 0.5㎖/㎏) and basal diet for 2 weeks, Sample A group was injected carbon tetrachloride(CCI₄0.5㎖/㎏) and fed the Bahasasimtang extract(10㎖/㎏) for 2 weeks, Sample A group was injected carbon tetrachloride(CCI₄ 0.5㎖/㎏) and fed the Banhasasimtang extract(10㎖/㎏) for 2 weeks, Sample B group was fed the Banhasasimtang extract(10㎖/㎏) for 2 weeks and injected carbon tetrachloride(CCI₄ 0.5㎖/㎏), Sample C group was fed the Banhasasimtang extract(10㎖/㎏) for 2 weeks.
The change of GOT, GPT, γ-GPT, ALP, LDH activity and Bilirubin level in blood serum. The obtained results are summarized as follows :
1. In the change of GOT GPT contents, as compared with control group, sample group was significantly decreased.
2. In the change of γ-GPT contents, as compared wth control group, sample group was significantly decreased.
3. In the change of ALP contents, as compared with control group, sample group was significantly decreased.
4. In the change of LDP contents, as compared with control group, sample group was significantly decreased.
5. In the change of Bilirubin contents, as compared with control group, sample group was significantly decreased.
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KEYWORD
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